A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data
 
Probabilistic interactomes
 
PIP PIP(Lcut = 600) PIP(Lcut = 300)
 
PIT PIT(Lcut = 600) PIT(Lcut = 300)
 
PIE PIE(Lcut = 600) PIE(Lcut = 300)

 Graph of PIP (Lcut = 600) and gold standard positives

 Graph of PIP (Lcut = 600) and gold standard negatives




Genomic features
   Essentiality data
   Functional similarity data  (MIPS  + GO)
   mRNA expression data
   Conditional indepence of genomic features




Gold standard positives
   Positives (subset of MIPS complexes)
   Negatives






 Description of datasets
 
Browse the Probabilistic Interactomes
PIP
PIE
PIT
 ORF

Lcut
Lcut = likelihood ratio cutoff

Paper

Supplementary Data
Presentation at GCB 2003

Report on Chemical & Engineering News



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 Last modified March 2004
 Copyright 2003.Yale Gerstein Lab