Name Signal1 Pro_pro interaction Kinase substrate localization Essentiality MIPS annotation Common name SGD annotation YAL028W 19554.29217 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YAR014C 35227.77201 0 0 - Non-essen Genes - BUD14 bud neck bud tip incipient bud site molecular_function unknown bud site selection filamentous growth YBL011W 36750.37889 0 0 - Non-essen Genes - SCT1 cellular_component unknown glycerol-3-phosphate O-acyltransferase glycerol-3-phosphate O-acyltransferase glycerol-3-phosphate O-acyltransferase phospholipid biosynthesis phospholipid biosynthesis YBL047C 27635.80799 0 0 - Non-essen Genes - EDE1 actin cortical patch (sensu Saccharomyces) bud neck bud tip molecular_function unknown endocytosis YBL057C 13557.95172 0 0 cyt Non-essen Genes - PTH2 cytoplasm aminoacyl-tRNA hydrolase aminoacyl-tRNA hydrolase protein biosynthesis YBL061C 13331.06933 0 0 - Non-essen Genes - SKT5 contractile ring (sensu Saccharomyces) enzyme activator cell wall chitin biosynthesis cytokinesis response to osmotic stress YBL095W 17051.2418 0 0 mit Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YBR231C 16081.67434 0 0 cyt Non-essen Genes - AOR1 cellular_component unknown molecular_function unknown biological_process unknown YBR264C 21250.81943 0 0 - Non-essen Genes 61.21.21 YPT10 cellular_component unknown guanyl nucleotide binding Golgi organization and biogenesis YCL029C 19668.5 0 0 nuc Non-essen Genes - BIK1 spindle microtubule spindle pole body microtubule binding mitotic anaphase B mitotic spindle assembly YCR064C 11393.48959 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YDL070W 36732.31283 0 0 nuc Non-essen Genes - BDF2 nucleus molecular_function unknown biological_process unknown YDL070W 25897.20448 0 0 nuc Non-essen Genes - BDF2 nucleus molecular_function unknown biological_process unknown YDL115C 13330 0 0 cyt Non-essen Genes - IWR1 cellular_component unknown molecular_function unknown biological_process unknown YDL230W 15416.41399 0 0 cyt Non-essen Genes 181.11.31 PTP1 cellular_component unknown protein tyrosine phosphatase protein tyrosine phosphatase protein amino acid dephosphorylation protein amino acid dephosphorylation YDL231C 13414.67982 0 0 - Non-essen Genes - BRE4 integral to membrane molecular_function unknown endocytosis YDR034CC 10486.75 0 0 - Non-essen Genes - LYS14 nucleus transcriptional activator transcriptional activator "lysine biosynthesis, aminoadipic pathway" YDR054C 19632 0 0 nuc Essentail Genes 191.31 CDC34 nuclear ubiquitin ligase complex ubiquitin conjugating enzyme ubiquitin-protein ligase G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle ubiquitin-dependent protein catabolism YDR145W 10436.00592 0 0 nuc Essentail Genes - TAF12 SAGA complex transcription factor TFIID complex general RNA polymerase II transcription factor G1-specific transcription in mitotic cell cycle chromatin modification establishment and/or maintenance of chromatin architecture histone acetylation protein amino acid acetylation transcription initiation from Pol II promoter YDR214W 11647.63659 0 0 - Non-essen Genes - AHA1 cellular_component unknown chaperone activator chaperone activator protein folding protein folding response to stress response to stress response to stress YDR229W 18395.34838 0 0 - Non-essen Genes - IVY1 vacuolar membrane (sensu Fungi) phospholipid binding secretory pathway secretory pathway YDR312W 15917.08247 0 0 - Non-essen Genes - SSF2 nucleolus rRNA binding conjugation with cellular fusion ribosomal large subunit assembly and maintenance ribosomal large subunit assembly and maintenance YDR316W 14027.05952 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YDR328C 17624.36201 0 0 nuc Essentail Genes - SKP1 nuclear ubiquitin ligase complex ubiquitin-protein ligase G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle ubiquitin-dependent protein catabolism YDR330W 13267.78474 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown ubiquitin-dependent protein catabolism YDR346C 21321.21347 0 0 cyt Non-essen Genes - SGI1 cellular_component unknown molecular_function unknown biological_process unknown YDR443C 35061.52219 0 0 - Non-essen Genes 141.21.21 SSN2 transcription factor complex general RNA polymerase II transcription factor negative regulation of transcription from Pol II promoter YEL012W 19611.36996 0 0 cyt Non-essen Genes 191.31 UBC8 cytoplasm ubiquitin conjugating enzyme protein monoubiquitination protein polyubiquitination YER024W 15502.03046 0 0 mit Non-essen Genes - YAT2 cellular_component unknown carnitine O-acetyltransferase alcohol metabolism alcohol metabolism carnitine metabolism YER027C 14408.25392 0 0 - Non-essen Genes - GAL83 nucleus SNF1A/AMP-activated protein kinase protein amino acid phosphorylation signal transduction YER079W 9343.5 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YER116C 20514.94522 0 0 - Non-essen Genes - SLX8 nucleus DNA binding DNA recombination DNA recombination YER122C 14923.4006 0 0 cyt Non-essen Genes 201.21.99 GLO3 ER-Golgi intermediate compartment ARF GTPase activator ER to Golgi transport ER to Golgi transport retrograde (Golgi to ER) transport retrograde (Golgi to ER) transport retrograde (Golgi to ER) transport YFR021W 15919.42966 0 0 - Non-essen Genes - AUT10 cytosol molecular_function unknown autophagy autophagy protein-vacuolar targeting protein-vacuolar targeting sporulation (sensu Saccharomyces) sporulation (sensu Saccharomyces) sporulation (sensu Saccharomyces) vacuolar protein processing/maturation vacuolar protein processing/maturation YFR029W 18991.09817 0 0 - Essentail Genes - PTR3 extrinsic to plasma membrane amino acid binding amino acid binding chemosensory perception chemosensory perception YFR038W 14992.8182 0 0 nuc Non-essen Genes - cellular_component unknown helicase biological_process unknown YGL056C 32346.88889 0 0 nuc Non-essen Genes - SDS23 cytoplasm nucleus molecular_function unknown biological_process unknown YGL079W 52690.02212 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YGL100W 13436.6174 0 0 nuc Non-essen Genes - SEH1 nuclear pore structural molecule NLS-bearing substrate-nucleus import mRNA-binding (hnRNP) protein-nucleus import mRNA-nucleus export nuclear pore organization and biogenesis protein-nucleus export rRNA-nucleus export ribosomal protein-nucleus import snRNA-nucleus export snRNP protein-nucleus import tRNA-nucleus export YGL105W 12524.35917 0 0 cyt Non-essen Genes - ARC1 cytoplasm methionyl glutamyl tRNA synthetase complex methionyl glutamyl tRNA synthetase complex tRNA binding tRNA binding amino acid activation tRNA-nucleus export YGL207W 40713.33099 0 0 nuc Essentail Genes - SPT16 alpha DNA polymerase:primase complex chromatin transcription elongation factor complex Pol II transcription elongation factor transcription elongation factor RNA elongation from Pol II promoter chromatin modeling regulation of global transcription from Pol II promoter YGL209W 15311.66897 0 0 nuc Non-essen Genes 201.21.21 MIG2 nucleus specific RNA polymerase II transcription factor glucose metabolism regulation of transcription from Pol II promoter YGR017W 12454.37969 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YGR038CA 15789.25 0 0 - Non-essen Genes - YGR038W 33818.86696 0 0 - Non-essen Genes - ORM1 cellular_component unknown molecular_function unknown biological_process unknown YGR100W 19830.504 0 0 cyt Non-essen Genes - MDR1 soluble fraction RAB GTPase activator RAB GTPase activator biological_process unknown YGR153W 20785.86958 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YGR159C 15848.51781 0 0 nuc Non-essen Genes - NSR1 nucleolus nucleus RNA binding single-stranded DNA binding rRNA processing ribosomal small subunit assembly and maintenance YGR167W 27031.38597 0 0 cyt Non-essen Genes - CLC1 clathrin vesicle coat structural molecule vesicle-mediated transport YGR240C 13924.18334 0 0 cyt Non-essen Genes - PFK1 6-phosphofructokinase complex cytoplasm 6-phosphofructokinase glycolysis YHL024W 17921.746 0 0 cyt Non-essen Genes - RIM4 cytoplasm RNA binding RNA binding meiosis meiosis meiotic recombination premeiotic DNA synthesis sporulation sporulation YHR090C 16330.28129 0 0 - Non-essen Genes - YNG2 histone acetyltransferase complex nucleus enzyme activator chromatin modification chromatin modification chromatin modification YHR133C 20160 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YHR142W 16832.75 0 0 - Non-essen Genes - CHS7 endoplasmic reticulum membrane molecular_function unknown ER to Golgi transport cell wall chitin biosynthesis YHR156C 20147.1679 0 0 cyt Non-essen Genes 131.21 LIN1 nucleus molecular_function unknown biological_process unknown YHR182W 15840.46811 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YIL034C 11550.40209 0 0 cyt Non-essen Genes - CAP2 actin capping protein complex actin cortical patch (sensu Saccharomyces) F-actin capping actin filament organization cell wall organization and biogenesis endocytosis response to osmotic stress YIL077C 17574.20894 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YIL091C 13786.35036 0 0 - Essentail Genes - cellular_component unknown molecular_function unknown biological_process unknown YIL107C 7927.043 0 1 cyt Non-essen Genes - PFK26 cytoplasm 6-phosphofructo-2-kinase 6-phosphofructo-2-kinase "fructose 2,6-bisphosphate metabolism" regulation of glycolysis YIL148W 12541.58126 0 0 cyt Non-essen Genes 191.11 RPL40A cytosolic large ribosomal subunit (sensu Eukarya) protein tagging structural constituent of ribosome protein biosynthesis ubiquitin-dependent protein catabolism YIR003W 18198.57863 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YJL084C 21594.88883 0 0 cyt Non-essen Genes - cytoplasm cyclin binding biological_process unknown YJR092W 29586.48722 0 0 - Non-essen Genes - BUD4 contractile ring (sensu Saccharomyces) GTP binding axial budding bud site selection YKL042W 14274.52004 0 0 nuc Essentail Genes - SPC42 central plaque of spindle pole body intermediate layer of spindle pole body structural constituent of cytoskeleton microtubule nucleation spindle pole body duplication (sensu Saccharomyces) YKL051W 18108.05959 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YKL121W 13482.73864 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YKL160W 50881.05325 0 0 nuc Non-essen Genes - ELF1 cellular_component unknown molecular_function unknown cell growth YKL160W 48094.32384 0 0 nuc Non-essen Genes - ELF1 cellular_component unknown molecular_function unknown cell growth YKL181W 13729.25 0 0 - Non-essen Genes - PRS1 cellular_component unknown ribose-phosphate pyrophosphokinase 'de novo' IMP biosynthesis 'de novo' pyrimidine base biosynthesis histidine biosynthesis purine salvage tryptophan biosynthesis YKR071C 30977.40929 0 0 - Essentail Genes - DRE2 cellular_component unknown molecular_function unknown biological_process unknown YKR079C 18819.98424 0 0 - Essentail Genes - cellular_component unknown purine nucleotide binding biological_process unknown YKR092C 17713.5 0 0 nuc Non-essen Genes - SRP40 nucleolus chaperone nucleocytoplasmic transport YKR094C 12990.15958 0 0 cyt Non-essen Genes 191.11 RPL40B cytosolic large ribosomal subunit (sensu Eukarya) protein tagging structural constituent of ribosome protein biosynthesis ubiquitin-dependent protein catabolism YLL008W 18227.69251 0 0 nuc Essentail Genes - DRS1 nucleolus ATP dependent RNA helicase 35S primary transcript processing ribosomal large subunit assembly and maintenance YLL022C 17015.97233 0 0 - Non-essen Genes - HIF1 cellular_component unknown molecular_function unknown biological_process unknown YLL028W 16288.85995 0 0 - Non-essen Genes 121 TPO1 vacuolar membrane spermidine transporter spermine transporter polyamine transport YLL043W 17833.60609 0 0 - Non-essen Genes - FPS1 cytoplasm integral to plasma membrane plasma membrane transporter transporter transporter conjugation with cellular fusion transport YLR055C 13123.32329 0 0 nuc Non-essen Genes - SPT8 SAGA complex nucleus transcription cofactor transcription cofactor chromatin modification histone acetylation YLR125W 22819.499 0 0 - Non-essen Genes - molecular_function unknown biological_process unknown YLR132C 19346.62187 0 0 - Essentail Genes - cellular_component unknown molecular_function unknown biological_process unknown YLR215C 12347.86176 0 0 cyt Essentail Genes - CDC123 cellular_component unknown molecular_function unknown biological_process unknown YLR231C 10139.36105 0 0 - Non-essen Genes - BNA5 cellular_component unknown kynureninase nicotinamide adenine dinucleotide biosynthesis nicotinamide adenine dinucleotide biosynthesis YLR309C 15166.10509 0 0 cyt Non-essen Genes - IMH1 cytosol molecular_function unknown vesicle-mediated transport YLR350W 18119.56985 0 0 - Non-essen Genes - ORM2 endoplasmic reticulum membrane molecular_function unknown biological_process unknown YML037C 13336.25 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YML045WA 25175.90983 0 0 - Non-essen Genes - molecular_function unknown biological_process unknown YMR039C 15956.69723 0 0 nuc Non-essen Genes - SUB1 nucleus transcription co-activator transcription co-activator transcription co-activator positive regulation of transcription from Pol II promoter positive regulation of transcription from Pol II promoter positive regulation of transcription from Pol II promoter transcription termination from Pol II promoter YMR049C 23889.75 0 0 - Essentail Genes - ERB1 cellular_component unknown molecular_function unknown rRNA processing YMR165C 28412.50012 0 0 mit Non-essen Genes - SMP2 cellular_component unknown molecular_function unknown aerobic respiration plasmid maintenance YMR173W 22491.10385 0 0 cyt Non-essen Genes 101.99 DDR48 cellular_component unknown molecular_function unknown DNA repair DNA repair YMR205C 18780.62415 0 0 cyt Non-essen Genes - PFK2 6-phosphofructokinase complex cytoplasm 6-phosphofructokinase glycolysis YNL027W 34426.9448 0 0 - Non-essen Genes 201.21.21 CRZ1 cytoplasm nucleus DNA binding transcription factor transcription factor transcription factor calcium-mediated signaling calcium-mediated signaling calcium-mediated signaling "regulation of transcription, DNA-dependent" YNL066W 24570.99236 0 0 - Non-essen Genes - SUN4 cell wall mitochondrial matrix glucosidase mitochondrion organization and biogenesis YNL125C 22889.71487 0 0 - Non-essen Genes 121 ESBP6 membrane mitochondrion monocarboxylic acid transporter monocarboxylic acid transporter transporter transport YNL145W 14851.61456 0 0 en2 Non-essen Genes - MFA2 extracellular pheromone signal transduction during conjugation with cellular fusion signal transduction during conjugation with cellular fusion YNL186W 29599.30454 0 0 nuc Non-essen Genes 191.51 UBP10 nucleus ubiquitin-specific protease protein deubiquitination YNL192W 19610.56923 0 0 - Non-essen Genes - CHS1 chitosome plasma membrane chitin synthase budding YNL206C 31708.81868 0 0 nuc Non-essen Genes - RTT106 cellular_component unknown molecular_function unknown negative regulation of DNA transposition YNL212W 25993.73653 0 0 cyt Non-essen Genes - VID27 cellular_component unknown molecular_function unknown biological_process unknown YNL227C 28864.64229 0 0 cyt Non-essen Genes 201.21.21 cellular_component unknown molecular_function unknown endocytosis YNL272C 56240.88803 0 0 cyt Essentail Genes - SEC2 cytoplasmic vesicle cytosol guanyl-nucleotide exchange factor exocytosis YNL277W 34998.66871 0 0 cyt Non-essen Genes - MET2 cytoplasm homoserine O-acetyltransferase homoserine metabolism methionine biosynthesis YOR078W 14210.35591 0 0 - Non-essen Genes - BUD21 small nucleolar ribonucleoprotein complex snoRNA binding processing of 20S pre-rRNA processing of 20S pre-rRNA YOR101W 16044 0 0 - Non-essen Genes 61.21.41 RAS1 plasma membrane RAS small monomeric GTPase "G-protein signaling, adenylate cyclase activating pathway" RAS protein signal transduction cell proliferation YOR123C 18867.92684 0 0 nuc Non-essen Genes - LEO1 Cdc73/Paf1 complex transcription elongation factor complex Pol II transcription elongation factor RNA elongation from Pol II promoter transcription from Pol II promoter YOR141C 30020.4554 0 0 - Non-essen Genes 23 ARP8 nucleus molecular_function unknown biological_process unknown YOR239W 17679.04756 0 0 mit Non-essen Genes - ABP140 actin filament actin filament actin cross-linking actin cytoskeleton organization and biogenesis YOR254C 26053.75 0 0 - Essentail Genes 101.61 SEC63 endoplasmic reticulum membrane endoplasmic reticulum receptor "SRP-dependent, co-translational membrane targeting, translocation" YOR340C 35759.79729 0 0 nuc Essentail Genes 141.21.11 RPA43 DNA-directed RNA polymerase I complex DNA-directed RNA polymerase I transcription from Pol I promoter YPL023C 28570.12444 0 0 - Non-essen Genes - MET12 cell methylenetetrahydrofolate reductase (NADPH) methionine metabolism YPL181W 15017.45831 0 0 nuc Non-essen Genes - RXT1 cellular_component unknown molecular_function unknown biological_process unknown YPL236C 20053.31349 0 0 mit Non-essen Genes 161.51.11 cellular_component unknown protein kinase biological_process unknown YPL257WA 19093.33919 0 0 - Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown YPR024W 13571.76165 0 0 - Non-essen Genes 151 YME1 mitochondrial inner membrane mitochondrion ATP-dependent peptidase mitochondrion organization and biogenesis YPR082C 17230.50116 0 0 - Essentail Genes - DIB1 small nuclear ribonucleoprotein complex pre-mRNA splicing factor mRNA splicing mRNA splicing YPR137CA 18821.44973 0 0 - Non-essen Genes - YPR139C 12349.93813 0 0 cyt Non-essen Genes - VPS66 cytoplasm molecular_function unknown protein-vacuolar targeting YPR152C 26617.21232 0 0 cyt Non-essen Genes - cellular_component unknown molecular_function unknown biological_process unknown