factor	adjR2	pval	term	coeff	coeff_est_pval	coeff_est_sign_code	sig_level	
factor.Chl_a_Month	0.5897	1.356e-05	K00072(Synthesis and degradation of ketone bodies))	3.226e-01	0.03054	*	
factor.Chl_a_Month	0.5897	1.356e-05	K00100(Biosynthesis of steroids))	-2.517e-01	0.12557	
factor.Chl_a_Month	0.5897	1.356e-05	K00195(Photosynthesis))	-3.710e-01	0.06243	.	
factor.Chl_a_Month	0.5897	1.356e-05	K00564())	2.838e-01	0.05814	.	
factor.Chl_a_Month	0.5897	1.356e-05	K00624())	-4.525e-01	0.00847	**	
factor.Chl_a_Month	0.5897	1.356e-05	K00626(Nitrobenzene degradation))	-2.635e-01	0.09885	.	
factor.Chl_a_Month	0.5897	1.356e-05	K00710(Carbon fixation))	-4.879e-01	0.00211	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10008(Entner-Doudoroff pathway))	2.961e-01	0.000564	***	
factor.Chl_a_Month	0.8644	2.658e-08	M10013(Glyoxylate biosynthesis, glycolate => glyoxylate))	3.995e-01	0.001943	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10027(Valine biosynthesis, pyruvate => valine))	2.246e-01	0.057825	.	
factor.Chl_a_Month	0.8644	2.658e-08	M10056(S-Adenosylmethionine biosynthesis, methionine => S-adenosylmethionine => methionine))	3.361e-01	0.001379	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10076(Dopamine / noradrenaline / adrenaline metabolism))	2.986e-01	0.123281	
factor.Chl_a_Month	0.8644	2.658e-08	M10095(Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP))	1.322e-01	0.219649	
factor.Chl_a_Month	0.8644	2.658e-08	M10155(Keratan sulfate degradation))	3.692e-01	0.000994	***	
factor.Chl_a_Month	0.8644	2.658e-08	M10177(Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone))	-3.372e-01	0.004362	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10197(C40 isoprenoid biosynthesis, GGAP => lycopene))	5.922e-01	0.003631	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10228(Bile acid biosynthesis, cholesterol => chenodeoxycholate/lithocholate))	-5.210e-01	0.034585	*	
factor.Chl_a_Month	0.8644	2.658e-08	M10247(Cobalamin biosynthesis, cobinamide => cobalamin))	2.654e-01	0.075343	.	
factor.Chl_a_Month	0.8644	2.658e-08	M10259(Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate))	-4.801e-01	0.000306	***	
factor.Chl_a_Month	0.8644	2.658e-08	M10274(Complex I (NADH dehydrogenase), NADH dehydrogenase I/diaphorase subunit of the bidirectional hydrogenase))	-6.262e-01	0.050166	.	
factor.Chl_a_Month	0.8644	2.658e-08	M10290(Photosystem II))	-4.636e-01	0.009320	**	
factor.Chl_a_Month	0.8644	2.658e-08	M10306(Sulfur reduction, sulfate => H2S))	5.486e-01	0.000130	***	
factor.local_sal	0.5825	1.708e-05	M10020(Proline biosynthesis, glutamate => proline))	0.3836966	0.03521	*	
factor.local_sal	0.5825	1.708e-05	M10022(Asparagine biosynthesis, aspartate => asparagine))	0.3805404	0.01285	*	
factor.local_sal	0.5825	1.708e-05	M10032(Cysteine biosynthesis, serine => cysteine))	0.3182754	0.04213	*	
factor.local_sal	0.5825	1.708e-05	M10041(Ornithine biosynthesis, glutamate => ornithine))	-0.3574904	0.01812	*	
factor.local_sal	0.5825	1.708e-05	M10159(Fatty acid biosynthesis, initiation))	0.4092543	0.00748	**	
factor.local_sal	0.5825	1.708e-05	M10228(Bile acid biosynthesis, cholesterol => chenodeoxycholate/lithocholate))	-0.2467185	0.14473	
factor.local_sal	0.5825	1.708e-05	M10303(Methane oxidation, methylotroph, methane => CO2))	0.3077812	0.06362	.	
factor.local_sal	0.6917	6.319e-06	K00100(Biosynthesis of steroids))	-0.3122816	0.05221	.	
factor.local_sal	0.6917	6.319e-06	K00150(Androgen and estrogen metabolism))	0.3581918	0.04311	*	
factor.local_sal	0.6917	6.319e-06	K00195(Photosynthesis))	0.4996747	0.00172	**	
factor.local_sal	0.6917	6.319e-06	K00252(Alanine and aspartate metabolism))	0.2696417	0.11641	
factor.local_sal	0.6917	6.319e-06	K00362(Benzoate degradation via hydroxylation))	-0.5406673	0.00124	**	
factor.local_sal	0.6917	6.319e-06	K00460(Cyanoamino acid metabolism))	-0.1827766	0.11040	
factor.local_sal	0.6917	6.319e-06	K00473(D-Alanine metabolism))	-0.3877041	0.02533	*	
factor.local_sal	0.6917	6.319e-06	K00561(Glycerolipid metabolism))	-0.2624288	0.02662	*	
factor.local_sal	0.6917	6.319e-06	K00625(Tetrachloroethene degradation))	0.2931509	0.02958	*	
factor.local_sal	0.6917	6.319e-06	K00642(Ethylbenzene degradation))	0.6875041	0.00166	**	
factor.local_sal	0.6917	6.319e-06	K00710(Carbon fixation))	0.4191253	0.00971	**	
factor.local_temp	0.4977	0.001961	K00071(Fatty acid metabolism))	5.851e-01	0.0779	.	
factor.local_temp	0.4977	0.001961	K00100(Biosynthesis of steroids))	4.450e-01	0.0247	*	
factor.local_temp	0.4977	0.001961	K00252(Alanine and aspartate metabolism))	-3.401e-01	0.1430	
factor.local_temp	0.4977	0.001961	K00350(Tyrosine metabolism))	6.911e-01	0.0142	*	
factor.local_temp	0.4977	0.001961	K00362(Benzoate degradation via hydroxylation))	-5.245e-01	0.0418	*	
factor.local_temp	0.4977	0.001961	K00401())	-3.496e-01	0.1129	
factor.local_temp	0.4977	0.001961	K00521(Streptomycin biosynthesis))	3.588e-01	0.1574	
factor.local_temp	0.4977	0.001961	K00630(Glyoxylate and dicarboxylate metabolism))	4.280e-01	0.1598	
factor.local_temp	0.4977	0.001961	K00680(Methane metabolism))	-5.975e-01	0.0901	.	
factor.local_temp	0.4977	0.001961	K00710(Carbon fixation))	4.986e-01	0.0286	*	
factor.local_temp	0.4977	0.001961	K00950(Alkaloid biosynthesis I))	5.310e-01	0.0310	*	
factor.local_temp	0.4977	0.001961	K00980())	-4.241e-01	0.1704	
factor.local_temp	0.6816	5.787e-05	M10055(Methionine degradation))	-6.626e-01	0.01714	*	
factor.local_temp	0.6816	5.787e-05	M10056(S-Adenosylmethionine biosynthesis, methionine => S-adenosylmethionine => methionine))	4.322e-01	0.11280	
factor.local_temp	0.6816	5.787e-05	M10076(Dopamine / noradrenaline / adrenaline metabolism))	3.239e-01	0.09323	.	
factor.local_temp	0.6816	5.787e-05	M10097(UDP-glucose and UDP-galactose biosynthesis))	2.403e-01	0.11380	
factor.local_temp	0.6816	5.787e-05	M10101(UDP-N-Acetylgalactosamine and UDP-N-acetylmannosamine biosynthesis))	2.790e-01	0.10736	
factor.local_temp	0.6816	5.787e-05	M10177(Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone))	2.219e-01	0.23048	
factor.local_temp	0.6816	5.787e-05	M10186(Phosphatidylethanolamine (PE) biosynthesis, PS => PE))	-2.049e-01	0.15119	
factor.local_temp	0.6816	5.787e-05	M10192(C5 isoprenoid biosynthesis, non-mevalonate pathway))	2.681e-01	0.06129	.	
factor.local_temp	0.6816	5.787e-05	M10197(C40 isoprenoid biosynthesis, GGAP => lycopene))	-6.572e-01	0.00565	**	
factor.local_temp	0.6816	5.787e-05	M10227(Bile acid biosynthesis, cholesterol => cholate/deoxycholate))	-4.425e-01	0.00661	**	
factor.local_temp	0.6816	5.787e-05	M10290(Photosystem II))	6.303e-01	0.00428	**	
factor.local_temp	0.6816	5.787e-05	M10299(C4-dicarboxylic acid cycle, phosphoenolpyruvate carboxykinase type))	4.704e-01	0.00671	**	
factor.local_temp	0.6816	5.787e-05	M10300(C4-dicarboxylic acid cycle, NAD+ -malic enzyme type))	-2.890e-01	0.05499	.	
factor.local_temp	0.6816	5.787e-05	M10303(Methane oxidation, methylotroph, methane => CO2))	-3.313e-01	0.08695	.	
factor.sample_depth	0.7052	1.508e-07	K00020(Citrate cycle (TCA cycle)))	0.74840	3.88e-05	***	
factor.sample_depth	0.7052	1.508e-07	K00072(Synthesis and degradation of ketone bodies))	-0.35355	0.015285	*	
factor.sample_depth	0.7052	1.508e-07	K00350(Tyrosine metabolism))	-0.63203	0.000362	***	
factor.sample_depth	0.7052	1.508e-07	K00362(Benzoate degradation via hydroxylation))	-0.30781	0.060948	.	
factor.sample_depth	0.7052	1.508e-07	K00600(Sphingoglycolipid metabolism))	0.51695	6.60e-06	***	
factor.sample_depth	0.7052	1.508e-07	K00680(Methane metabolism))	0.36610	0.022888	*	
factor.sample_depth	0.7052	1.508e-07	K00720(Reductive carboxylate cycle (CO2 fixation)))	-0.84526	0.000150	***	
factor.sample_depth	0.7793	3.075e-07	M10009(Citrate cycle))	0.39916	0.005733	**	
factor.sample_depth	0.7793	3.075e-07	M10078(Tyrosine degradation, tyrosine => homogentisate))	-0.37463	0.007729	**	
factor.sample_depth	0.7793	3.075e-07	M10095(Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP))	0.29506	0.075263	.	
factor.sample_depth	0.7793	3.075e-07	M10104(CMP-N-Acetylneuraminate biosynthesis (mammals), ManNAc => Neu5Ac-9P => CMP-Neu5Ac))	0.48351	0.000153	***	
factor.sample_depth	0.7793	3.075e-07	M10118(Pentose interconversion, arabinose/ribulose/xylulose/xylose))	0.25383	0.024979	*	
factor.sample_depth	0.7793	3.075e-07	M10120(ADP-L-glycero-D-manno-heptose biosynthesis))	-0.22678	0.074132	.	
factor.sample_depth	0.7793	3.075e-07	M10204(CDP-diacylglycerol biosynthesis, PA => CDP-diacylglycerol))	-0.28011	0.006579	**	
factor.sample_depth	0.7793	3.075e-07	M10227(Bile acid biosynthesis, cholesterol => cholate/deoxycholate))	0.41878	0.002464	**	
factor.sample_depth	0.7793	3.075e-07	M10246(Heme biosynthesis, glutamate => protoheme/siroheme))	0.18342	0.066464	.	
factor.sample_depth	0.7793	3.075e-07	M10274(Complex I (NADH dehydrogenase), NADH dehydrogenase I/diaphorase subunit of the bidirectional hydrogenase))	0.33834	0.020840	*	
factor.sample_depth	0.7793	3.075e-07	M10288(V-type ATPase (Prokaryotes)))	-0.31672	0.003169	**	
factor.sample_depth	0.7793	3.075e-07	M10303(Methane oxidation, methylotroph, methane => CO2))	0.29193	0.025041	*	
factor.water_column_depth	0.5286	4.449e-05	K00030(Pentose phosphate pathway))	-0.2439116	0.06695	.	
factor.water_column_depth	0.5286	4.449e-05	K00072(Synthesis and degradation of ketone bodies))	-0.2960793	0.02955	*	
factor.water_column_depth	0.5286	4.449e-05	K00100(Biosynthesis of steroids))	0.2142523	0.10288	
factor.water_column_depth	0.5286	4.449e-05	K00550(Peptidoglycan biosynthesis))	-0.2822960	0.02730	*	
factor.water_column_depth	0.5286	4.449e-05	K00564())	-0.3696257	0.00563	**	
factor.water_column_depth	0.5286	4.449e-05	K00670(One carbon pool by folate))	0.1613367	0.18666	
factor.water_column_depth	0.7096	1.526e-06	M10008(Entner-Doudoroff pathway))	-0.4411689	0.000233	***	
factor.water_column_depth	0.7096	1.526e-06	M10024(Methionine biosynthesis, apartate => homoserine => methionine))	0.2929662	0.077118	.	
factor.water_column_depth	0.7096	1.526e-06	M10040(GABA (gamma-Aminobutyrate) shunt))	-0.5893431	0.002489	**	
factor.water_column_depth	0.7096	1.526e-06	M10063(Cysteine metabolism, cysteine => 3-mercaptopyruvate => pyruvate))	-0.1814027	0.115930	
factor.water_column_depth	0.7096	1.526e-06	M10090(Inosine monophosphate biosynthesis, PRPP + glutamine => IMP))	0.3141883	0.007737	**	
factor.water_column_depth	0.7096	1.526e-06	M10204(CDP-diacylglycerol biosynthesis, PA => CDP-diacylglycerol))	-0.4397269	0.000252	***	
factor.water_column_depth	0.7096	1.526e-06	M10245(Coenzyme A biosynthesis, pantothenate => CoA))	0.2034636	0.191624	
factor.water_column_depth	0.7096	1.526e-06	M10260(Polyamine biosynthesis, arginine => putrescine => spermidine))	-0.2822848	0.086970	.	
factor.water_column_depth	0.7096	1.526e-06	M10274(Complex I (NADH dehydrogenase), NADH dehydrogenase I/diaphorase subunit of the bidirectional hydrogenase))	-0.3267524	0.167975	
factor.water_column_depth	0.7096	1.526e-06	M10290(Photosystem II))	0.6986494	0.009167	**