K00251(Glutamate metabolism) 0.0189 10.0000 -0.0007 K00710(Carbon fixation) 0.0349 26.0000 -0.0007 K00030(Pentose phosphate pathway) 0.0411 35.0000 -0.0006 K00362(Benzoate degradation via hydroxylation) 0.0039 61.0000 0.0007 K00361(gamma-Hexachlorocyclohexane degradation) 0.0355 74.0000 0.0004 K00900(Terpenoid biosynthesis) 0.0192 85.0000 -0.0002 K00628(Fluorene degradation) 0.0347 88.0000 0.0003 K00590(Prostaglandin and leukotriene metabolism) 0.0327 91.0000 0.0003 K00627(1,4-Dichlorobenzene degradation) 0.0172 97.0000 0.0003 M10028(Leucine biosynthesis, pyruvate => leucine) 0.0217 4.0000 0.0012 M10246(Heme biosynthesis, glutamate => protoheme/siroheme) 0.0189 17.0000 -0.0013 M10027(Valine biosynthesis, pyruvate => valine) 0.0109 23.0000 0.0009 M10091(Adenine nucleotide biosynthesis, IMP => ADP/dADP,ATP/dATP) 0.0359 42.0000 0.0008 M10173(beta-Oxidation, acyl-CoA synthesis) 0.0419 73.0000 0.0005 M10013(Glyoxylate biosynthesis, glycolate => glyoxylate) 0.0161 104.0000 0.0008 M10156(Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen) 0.0200 120.0000 -0.0003 M10078(Tyrosine degradation, tyrosine => homogentisate) 0.0168 125.0000 0.0003 M10022(Asparagine biosynthesis, aspartate => asparagine) 0.0063 128.0000 -0.0004 M10046(Asparagine degradation, asparagine => aspartate +NH3) 0.0245 149.0000 -0.0003 M10202(Acylglycerol degradation) 0.0018 157.0000 0.0002 M10305(Nitrogen fixation, N2 => ammonia) 0.0047 165.0000 -0.0002 M10165(Eicosanoid biosynthesis, PGH2 => PGF2alpha) 0.0451 169.0000 0.0001 M10064(Cysteine metabolism, cysteine => pyruvate) 0.0433 178.0000 0.0001 M10086(Taurine biosynthesis, cysteine => hypotaurine => taurine) 0.0475 181.0000 -0.0001 M10087(Taurine biosynthesis, cysteine => cysteate => taurine) 0.0063 184.0000 -0.0001 clustr_3310 0.0073 48.0000 0.0007 clustr_4453 0.0024 53.0000 -0.0007 clustr_3631 0.0372 72.0000 -0.0005 clustr_3876 0.0418 81.0000 0.0004 clustr_4010 0.0005 84.0000 0.0023 clustr_4365 0.0180 94.0000 0.0003 clustr_3788 0.0057 108.0000 -0.0006 clustr_3024 0.0141 110.0000 -0.0006 clustr_4332 0.0324 113.0000 -0.0002 clustr_4287 0.0007 122.0000 -0.0006 clustr_4318 0.0007 168.0000 -0.0007 clustr_4353 0.0107 177.0000 -0.0005 clustr_4472 0.0007 189.0000 -0.0003 clustr_3116 0.0273 197.0000 0.0002 clustr_4273 0.0326 208.0000 -0.0002 clustr_2636 0.0047 214.0000 0.0002 clustr_3937 0.0002 217.0000 -0.0004 clustr_2620 0.0210 226.0000 -0.0002 clustr_4086 0.0416 235.0000 -0.0002 clustr_1177 0.0346 272.0000 0.0004 clustr_2957 0.0114 301.0000 -0.0002 clustr_3065 0.0002 306.0000 -0.0002 clustr_4342 0.0142 321.0000 0.0001 clustr_2990 0.0121 333.0000 0.0002 clustr_3223 0.0291 335.0000 -0.0001 clustr_3720 0.0478 343.0000 0.0002 clustr_2775 0.0165 354.0000 0.0002 clustr_2585 0.0029 361.0000 -0.0003 clustr_4390 0.0032 363.0000 -0.0002 clustr_3681 0.0208 380.0000 -0.0001 clustr_1918 0.0098 399.0000 -0.0002 clustr_2894 0.0106 429.0000 -0.0002 clustr_3270 0.0182 431.0000 0.0002 clustr_3181 0.0189 440.0000 -0.0001 clustr_4337 0.0453 445.0000 0.0001 clustr_4235 0.0181 488.0000 -0.0001 clustr_3078 0.0378 495.0000 0.0001 clustr_159 0.0495 503.0000 0.0001 clustr_2544 0.0019 511.0000 -0.0001 clustr_4308 0.0431 513.0000 -0.0002 clustr_4158 0.0323 515.0000 0.0001 clustr_4002 0.0058 527.0000 -0.0002 clustr_4263 0.0349 535.0000 0.0001 clustr_3722 0.0379 563.0000 -0.0001 clustr_2885 0.0311 567.0000 0.0002 clustr_2347 0.0007 569.0000 -0.0002 clustr_3554 0.0153 585.0000 0.0002 clustr_3900 0.0275 586.0000 0.0002 clustr_3424 0.0066 606.0000 -0.0001 clustr_4227 0.0177 621.0000 -0.0002 clustr_4122 0.0319 622.0000 -0.0001 clustr_3933 0.0250 639.0000 -0.0001 clustr_2599 0.0133 648.0000 0.0001 clustr_4249 0.0001 663.0000 -0.0001 clustr_3167 0.0015 668.0000 -0.0001 clustr_3359 0.0001 675.0000 -0.0001 clustr_3917 0.0475 677.0000 0.0001 clustr_2383 0.0367 702.0000 0.0001 clustr_4260 0.0494 718.0000 0.0001 clustr_4271 0.0015 731.0000 -0.0001 clustr_4021 0.0210 745.0000 -0.0000 COG0477(Permeases of the major facilitator superfamily) 0.0429 4.0000 0.0009 COG1372(Intein/homing endonuclease) 0.0130 18.0000 0.0005 COG2931(RTX toxins and related Ca2+-binding proteins) 0.0442 29.0000 -0.0006 COG0577(ABC-type antimicrobial peptide transport system, permease component) 0.0004 40.0000 -0.0004 COG1804(Predicted acyl-CoA transferases/carnitine dehydratase) 0.0212 103.0000 0.0003 COG3842(ABC-type spermidine/putrescine transport systems, ATPase components) 0.0125 110.0000 -0.0002 COG2204(Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains) 0.0366 113.0000 -0.0002 COG0556(Helicase subunit of the DNA excision repair complex) 0.0280 114.0000 -0.0002 COG0493(NADPH-dependent glutamate synthase beta chain and related oxidoreductases) 0.0190 128.0000 0.0002 COG0667(Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)) 0.0080 143.0000 0.0002 COG3321(Polyketide synthase modules and related proteins) 0.0452 155.0000 -0.0001 COG0143(Methionyl-tRNA synthetase) 0.0383 157.0000 -0.0001 COG0518(GMP synthase - Glutamine amidotransferase domain) 0.0462 160.0000 -0.0001 COG1178(ABC-type Fe3+ transport system, permease component) 0.0010 191.0000 -0.0003 COG1529(Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs) 0.0058 228.0000 0.0004 COG1304(L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases) 0.0114 280.0000 -0.0002 COG0668(Small-conductance mechanosensitive channel) 0.0411 285.0000 -0.0002 COG1702(Phosphate starvation-inducible protein PhoH, predicted ATPase) 0.0318 306.0000 0.0002 COG0124(Histidyl-tRNA synthetase) 0.0238 312.0000 -0.0001 COG0569(K+ transport systems, NAD-binding component) 0.0199 363.0000 -0.0001 COG0074(Succinyl-CoA synthetase, alpha subunit) 0.0230 370.0000 -0.0001 COG2885(Outer membrane protein and related peptidoglycan-associated (lipo)proteins) 0.0073 384.0000 -0.0002 COG0823(Periplasmic component of the Tol biopolymer transport system) 0.0202 389.0000 -0.0001 COG1840(ABC-type Fe3+ transport system, periplasmic component) 0.0404 399.0000 -0.0001 COG0123(Deacetylases, including yeast histone deacetylase and acetoin utilization protein) 0.0422 413.0000 -0.0001 COG0740(Protease subunit of ATP-dependent Clp proteases) 0.0321 423.0000 0.0002 COG1322(Uncharacterized protein conserved in bacteria) 0.0499 444.0000 -0.0001 COG1177(ABC-type spermidine/putrescine transport system, permease component II) 0.0130 449.0000 -0.0001 COG1176(ABC-type spermidine/putrescine transport system, permease component I) 0.0232 497.0000 -0.0001 COG0276(Protoheme ferro-lyase (ferrochelatase)) 0.0458 507.0000 -0.0001 COG2334(Putative homoserine kinase type II (protein kinase fold)) 0.0006 573.0000 -0.0002 COG1519(3-deoxy-D-manno-octulosonic-acid transferase) 0.0216 592.0000 -0.0002 COG3845(ABC-type uncharacterized transport systems, ATPase components) 0.0016 622.0000 -0.0002 COG0226(ABC-type phosphate transport system, periplasmic component) 0.0010 643.0000 0.0005 COG1073(Hydrolases of the alpha/beta superfamily) 0.0013 646.0000 -0.0002 COG0774(UDP-3-O-acyl-N-acetylglucosamine deacetylase) 0.0194 655.0000 -0.0001 COG0232(dGTP triphosphohydrolase) 0.0277 706.0000 -0.0001 COG0233(Ribosome recycling factor) 0.0053 788.0000 -0.0001 COG0394(Protein-tyrosine-phosphatase) 0.0357 797.0000 0.0001 COG0790(FOG: TPR repeat, SEL1 subfamily) 0.0182 806.0000 0.0001 COG0590(Cytosine/adenosine deaminases) 0.0095 809.0000 -0.0001 COG0234(Co-chaperonin GroES (HSP10)) 0.0479 818.0000 0.0001 COG0573(ABC-type phosphate transport system, permease component) 0.0020 824.0000 0.0003 COG4603(ABC-type uncharacterized transport system, permease component) 0.0108 835.0000 -0.0001 COG1079(Uncharacterized ABC-type transport system, permease component) 0.0351 875.0000 -0.0001 COG0581(ABC-type phosphate transport system, permease component) 0.0048 882.0000 0.0003 COG1201(Lhr-like helicases) 0.0054 889.0000 -0.0002 COG0820(Predicted Fe-S-cluster redox enzyme) 0.0216 892.0000 0.0001 COG4805(Uncharacterized protein conserved in bacteria) 0.0217 907.0000 0.0001 COG1117(ABC-type phosphate transport system, ATPase component) 0.0031 923.0000 0.0003 COG3653(N-acyl-D-aspartate/D-glutamate deacylase) 0.0183 963.0000 0.0001 COG1409(Predicted phosphohydrolases) 0.0017 968.0000 -0.0002 COG2908(Uncharacterized protein conserved in bacteria) 0.0218 985.0000 0.0001 COG0412(Dienelactone hydrolase and related enzymes) 0.0029 993.0000 0.0001 COG1256(Flagellar hook-associated protein) 0.0099 1007.0000 -0.0002 COG4985(ABC-type phosphate transport system, auxiliary component) 0.0084 1015.0000 0.0003 COG4886(Leucine-rich repeat (LRR) protein) 0.0356 1017.0000 0.0002 COG0506(Proline dehydrogenase) 0.0350 1034.0000 -0.0001 COG0306(Phosphate/sulphate permeases) 0.0344 1036.0000 -0.0001 COG4993(Glucose dehydrogenase) 0.0449 1044.0000 0.0002 COG0580(Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)) 0.0186 1052.0000 0.0001 COG4581(Superfamily II RNA helicase) 0.0460 1060.0000 0.0001 COG4631(Xanthine dehydrogenase, molybdopterin-binding subunit B) 0.0001 1077.0000 -0.0002 COG4172(ABC-type uncharacterized transport system, duplicated ATPase component) 0.0222 1118.0000 -0.0001 COG0241(Histidinol phosphatase and related phosphatases) 0.0104 1134.0000 0.0001 COG0704(Phosphate uptake regulator) 0.0113 1142.0000 0.0002 COG0300(Short-chain dehydrogenases of various substrate specificities) 0.0456 1150.0000 0.0001 COG4215(ABC-type arginine transport system, permease component) 0.0394 1172.0000 -0.0001 COG1981(Predicted membrane protein) 0.0058 1199.0000 0.0001 COG0651(Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit) 0.0086 1218.0000 -0.0001 NOG20044(Sulfotransferase) 0.0064 1228.0000 -0.0001 COG0218(Predicted GTPase) 0.0216 1236.0000 -0.0001 COG2159(Predicted metal-dependent hydrolase of the TIM-barrel fold) 0.0348 1299.0000 0.0001 NOG13248() 0.0324 1303.0000 -0.0001 COG0609(ABC-type Fe3+-siderophore transport system, permease component) 0.0146 1312.0000 -0.0001 COG3476(Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)) 0.0356 1317.0000 -0.0001 NOG13798() 0.0001 1318.0000 -0.0001 COG1749(Flagellar hook protein FlgE) 0.0254 1323.0000 -0.0001 COG0369(Sulfite reductase, alpha subunit (flavoprotein)) 0.0057 1330.0000 -0.0001 COG1666(Uncharacterized protein conserved in bacteria) 0.0079 1342.0000 0.0001 COG4630(Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A) 0.0003 1366.0000 -0.0001 NOG04035() 0.0218 1376.0000 -0.0001 COG2233(Xanthine/uracil permeases) 0.0027 1390.0000 -0.0001 COG2035(Predicted membrane protein) 0.0065 1409.0000 -0.0001 COG3786(Uncharacterized protein conserved in bacteria) 0.0114 1426.0000 -0.0001 COG0846(NAD-dependent protein deacetylases, SIR2 family) 0.0050 1435.0000 -0.0001 COG0603(Predicted PP-loop superfamily ATPase) 0.0399 1442.0000 0.0001 COG0780(Enzyme related to GTP cyclohydrolase I) 0.0120 1443.0000 0.0001 COG2259(Predicted membrane protein) 0.0376 1460.0000 -0.0000 NOG08489() 0.0180 1486.0000 0.0002 NOG30348() 0.0034 1514.0000 -0.0002 NOG06841() 0.0479 1518.0000 -0.0001 COG3164(Predicted membrane protein) 0.0379 1548.0000 0.0001 COG2095(Multiple antibiotic transporter) 0.0219 1550.0000 0.0001 NOG09465() 0.0031 1556.0000 -0.0001 COG4266(Allantoicase) 0.0030 1564.0000 -0.0001 NOG04772(Alkane-1 monooxygenase) 0.0374 1573.0000 -0.0001 COG1204(Superfamily II helicase) 0.0249 1611.0000 -0.0001 NOG24186() 0.0219 1612.0000 -0.0000 COG1763(Molybdopterin-guanine dinucleotide biosynthesis protein) 0.0061 1613.0000 -0.0000 COG1376(Uncharacterized protein conserved in bacteria) 0.0117 1640.0000 -0.0001 COG4198(Uncharacterized conserved protein) 0.0089 1656.0000 -0.0001 COG3840(ABC-type thiamine transport system, ATPase component) 0.0020 1664.0000 -0.0001 COG2057(Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit) 0.0413 1668.0000 0.0001 NOG16995() 0.0401 1670.0000 0.0001 COG1541(Coenzyme F390 synthetase) 0.0352 1674.0000 -0.0000 COG3194(Ureidoglycolate hydrolase) 0.0373 1707.0000 -0.0000 COG1486(Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases) 0.0012 1746.0000 -0.0001 COG2329(Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides) 0.0004 1762.0000 -0.0001 NOG09072(Alternative oxidase) 0.0014 1779.0000 -0.0001