During the past year the Gerstein lab initiated analyses of regulatory networks related to the yeast cell cycle. In Yu et al. we performed an analysis relating the "known" regulatory networks from the ChIP-chip experiments with inferred expression networks. We found a strong correlation in expression for proteins that were regulated by the same transcription factor and we also found that transcription factors tend to have time-shifted or inverted expression profiles with relation to their targets. In the following year we plan to carry on this analysis more and looking at further correlations relating to regulatory networks.
Genomic analysis of gene expression relationships in transcriptional regulatory networks.
H Yu, NM Luscombe, J Qian, M Gerstein (2003) Trends Genet 19: 422-7.