KS test - compare how similar distributions are - less power? sensitive? t test independence of values generate random 'pathways' (use as NULL, instead of what I did) and use for comparison there have to be tests or metrics that test significance of a ranked list gradient of the pathway - receptor proteins more variable - looking at levels (similar to hierarchy?) -> instead of looking at co-occurrence Jason Lu - surmounted 'download KEGG' issue? KEGG pathways - XML formats - parse XML files BioCarta - downloadable pathways - Cgap GSEA - gene-set enrichment analysis